Endocrine Abstracts

The first crystal structure of human androgen receptor (AR) homodimer will be presented. This structure allows for the structure-based rationalization of the largest number of disease-associated mutations described for the AR ligand binding domain (LBD), which have been involved in prostate cancer and androgen insensitivity syndromes. The conservation of essential residues involved in AR self-association in other oxosteroid receptors suggests a more common dimerization mechani...